Christrup L L, Angelo H R, Bonde J, Kristensen F, Rasmussen S N
Department of Pharmaceutics, Royal Danish-School of Pharmacy, Copenhagen.
Acta Pharm Nord. 1990;2(2):83-8.
Methadone administered in chewing gum in doses of 16.7-22.6 mg to seven patients in a study using an open balanced cross-over design, was compared with 20 mg of methadone given perorally as tablets. There was no significant difference in the AUC/D obtained after administration of chewing gum and tablets (p greater than 0.05). It is concluded that the chewing gum formulation should be considered for further testing with respect to suppression of abstinence syndrome in narcotic addicts.
在一项采用开放平衡交叉设计的研究中，对7名患者给予剂量为16.7 - 22.6毫克的美沙酮口香糖，并与口服20毫克美沙酮片剂进行比较。服用口香糖和美沙酮片剂后获得的AUC/D无显著差异（p大于0.05）。得出的结论是，就抑制吸毒成瘾者的戒断综合征而言，应考虑对口香糖制剂进行进一步测试。
