Brigham and Women's Hospital/Dana Farber Cancer Institute, Department of Obstetrics and Gynecology, New England Trophoblastic Disease Center, Harvard Medical School, Boston, MA 02115, USA.
Expert Opin Pharmacother. 2010 Dec;11(18):3027-39. doi: 10.1517/14656566.2010.512288. Epub 2010 Oct 19.
Gestational trophoblastic disease is one of the few human malignancies that is curable, even in advanced stages of the disease. However, appropriate management and follow-up are essential components in curing this disease.
Observational, retrospective and prospective studies evaluating the efficacy of medical and surgical management of gestational trophoblastic disease were analyzed to provide a comprehensive review of current and new treatment modalities. We searched PubMed, Medline and the Library of Congress from January 1965 to January 2010.
The reader will obtain information on how to classify gestational trophoblastic neoplasia (GTN) into low- and high-risk groups, as well as learn the medical and surgical management of low- and high-risk GTN and recurrent GTN. The effectiveness of treatment regimens and subsequent fertility is also reviewed.
GTN is highly responsive to chemotherapy. However, surgery is an important adjunct in select cases. Even in advanced-stage or recurrent disease, cure can be achieved and fertility preserved.
滋养细胞肿瘤是为数不多的人类恶性肿瘤之一，是可以治愈的，即使在疾病的晚期。然而，适当的管理和后续行动是治愈这种疾病的重要组成部分。
在这个审查中分析了观察、回顾性和前瞻性研究评估了医学和手术治疗滋养细胞肿瘤的疗效，以提供当前和新的治疗方法的全面审查。我们搜索了 PubMed、Medline 和美国国会图书馆从 1965 年 1 月至 2010 年 1 月。
读者将获得有关如何分类滋养细胞肿瘤（GTN）为低风险和高风险组，以及学习低风险和高风险的 GTN 和复发性 GTN 的医疗和手术管理。治疗方案的有效性和随后的生育能力也进行了回顾。
GTN 是高度响应化疗。然而，手术是一个重要的辅助手段在选择的情况下。即使在晚期或复发性疾病，治愈可以实现和生育力的保存。
