Burdzhanadze T V, Bezhitadze M O, Giorgadze A G, Babakishvili G M
Biofizika. 1990 Nov-Dec;35(6):933-7.
Activation parameters of fibril formation of evolutionary differing collagens were investigated. It has been shown that in a heated solution formation of collagen fibrils of different origin proceeds in different temperature regions related with the environmental temperature of species range. Enthalpy and free energy of the activation of fibril formation were measured. The data obtained show that fibril formation is preceded by the conformation of the molecules. Biological significance of the correspondence between the temperature of denaturation and that of the species range is discussed. The above correspondence is the limiting expression of functional dependence of conformational flexibility on temperature. Directed selection realized in the course of evolution is required for maintaining the velocity of collagen synthesis at the constant level.
研究了进化上不同的胶原蛋白原纤维形成的活化参数。结果表明，在加热溶液中，不同来源的胶原蛋白原纤维形成发生在与物种范围环境温度相关的不同温度区域。测量了原纤维形成活化的焓和自由能。所得数据表明，原纤维形成之前分子会发生构象变化。讨论了变性温度与物种范围温度之间对应关系的生物学意义。上述对应关系是构象灵活性对温度功能依赖性的极限表达。在进化过程中实现的定向选择对于将胶原蛋白合成速度维持在恒定水平是必需的。
