Pediatric Psychopharmacology Unit of the Psychiatry Department, Massachusetts General Hospital, Boson, Massachusetts 02114, USA.
Am J Addict. 2010 Nov-Dec;19(6):474-80. doi: 10.1111/j.1521-0391.2010.00077.x. Epub 2010 Sep 21.
We examined whether children and adolescents with bipolar disorder (BPD) "self-medicate" with cigarettes, alcohol, or other substances of abuse. One hundred and five adolescents with BPD and 98 controls were comprehensively assessed with a structured psychiatric diagnostic interview for psychopathology and the Drug Use Screening Inventory (DUSI) for self-medication. Thirteen control (mean ± standard deviation [SD]= 15.31 ± 1.18 years) and 27 BPD (15.30 ± 2.09 years) subjects endorsed use of one of the listed drugs in the DUSI Section A within the past year and were included in all analyses. BPD adolescents were more likely than nonmood disordered, substance-using controls to report starting to use their preferred drug for mood-altering effects. There were no differences between groups in motivation for use with respect to starting substances to sleep better or get high, or in continuing substances to change mood, sleep better, or get high. These data may contribute to increased prevention of substance use disorders and to the treatment of adolescent BPD. Further studies clarifying the characteristics of self-medication are necessary.
我们研究了双相情感障碍（BPD）儿童和青少年是否会“自我用药”，即使用香烟、酒精或其他滥用药物。我们对 105 名患有 BPD 的青少年和 98 名对照者进行了全面评估，采用结构化精神病学诊断访谈评估精神病理学，采用药物使用筛查清单（DUSI）评估自我用药情况。13 名对照者（平均±标准差[SD]=15.31±1.18 岁）和 27 名 BPD 者（15.30±2.09 岁）在过去一年中曾在 DUSI 量表 A 中列出的一种药物，他们都被包括在所有分析中。与非心境障碍、使用物质的对照者相比，BPD 青少年更有可能报告开始使用他们偏爱的药物来改变情绪。两组在开始使用药物改善睡眠、提高情绪，或继续使用药物改变情绪、改善睡眠或提高情绪的动机方面没有差异。这些数据可能有助于增加预防物质使用障碍和治疗青少年 BPD。有必要进一步研究澄清自我用药的特征。
