St. Dominic Savio Catholic High School, Austin, TX 78717, USA.
IEEE Trans Biomed Eng. 2011 Feb;58(2):397-403. doi: 10.1109/TBME.2010.2088122. Epub 2010 Oct 18.
A 3-D application-specific microelectrode array has been developed for physiological studies in guinea pig cochlear nucleus (CN). The batch-fabricated silicon probes contain integrated parylene cables and use a boron etch-stop to define 15μm-thick shanks and limit tissue displacement. Targeting the ventral (three probes) and dorsal (two probes) subnuclei, the custom four-shank 32-site probes are combined in a slotted block platform having a 1.18-mm (2) footprint. The device has permitted, for the first time, high-density 3-D in vivo studies of ventral CN to dorsal CN connections, stimulating with 1000 μm (2) sites in one subnucleus while recording with 177 μm (2) sites in the other. Through these experiments, it has demonstrated the efficacy of bimodal silicon arrays to better understand the central nervous system at the circuit level. The 160 electrode sites also provide a high-density neural interface, which is an essential aspect of auditory prosthesis prototypes.
已经开发出一种用于豚鼠耳蜗核（CN）生理研究的特定于 3-D 的微电极阵列。批量制造的硅探针包含集成的聚对二甲苯电缆，并使用硼蚀刻停止来定义 15μm 厚的柄部并限制组织位移。针对腹侧（三个探针）和背侧（两个探针）亚核，定制的四柄 32 位探针组合在具有 1.18-mm（2）足迹的开槽块平台上。该设备首次允许对腹侧 CN 到背侧 CN 连接进行高密度 3-D 体内研究，在一个亚核中用 1000μm（2）位点刺激，而在另一个亚核中用 177μm（2）位点记录。通过这些实验，证明了双模态硅阵列在以电路水平更好地理解中枢神经系统方面的有效性。160 个电极位点还提供了高密度的神经接口，这是听觉假体原型的一个重要方面。
