Department of Nephrology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Nephrol Dial Transplant. 2011 Jan;26(1):371-3. doi: 10.1093/ndt/gfq600. Epub 2010 Oct 19.
Human hepatitis B virus (HBV) is well known as a cause of membranous nephropathy (MN). While the association of HBV infection with MN is strong, data regarding its association with other glomerular diseases are conflicting. Here, we report a case of focal segmental glomerulosclerosis (FSGS) with HBV infection. In this case, we have found HBV-DNA in urinary podocytes by real-time PCR methods. After the administration of anti-viral therapy, FSGS improved, paralleling the decreased level of HBV-DNA in podocytes. The refractory FSGS induced by HBV could be effectively treated with appropriate anti-viral agents.
乙型肝炎病毒（HBV）是众所周知的导致膜性肾病（MN）的原因。虽然 HBV 感染与 MN 的关联很强，但关于其与其他肾小球疾病的关联的数据存在矛盾。在这里，我们报告了一例 HBV 感染引起的局灶节段性肾小球硬化症（FSGS）。在这种情况下，我们通过实时 PCR 方法在尿足细胞中发现了 HBV-DNA。抗病毒治疗后，FSGS 改善，与足细胞中 HBV-DNA 的水平下降平行。HBV 引起的难治性 FSGS 可以用适当的抗病毒药物有效治疗。
