Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, People's Republic of China.
Radiology. 2010 Nov;257(2):318-20. doi: 10.1148/radiol.10100775.
Lumbar spine disk degeneration is a common musculoskeletal condition, the prevalence of which increases with age (1-3). Disk degeneration can progress to disk herniation, spinal canal stenosis, and, in conjunction with facet joint arthrosis, degenerative spondylolisthesis. It remains not fully understood what factors initiate and influence the progression of disk degeneration. Nevertheless, there is general agreement that spinal mechanical stress accelerates the development of disk degeneration and increases the likelihood of disk herniation (4-6). Increasing evidence suggests that sex hormones also influence the severity of disk degeneration.
腰椎间盘退变是一种常见的肌肉骨骼疾病，其患病率随着年龄的增长而增加（1-3）。椎间盘退变可进展为椎间盘突出、椎管狭窄，并与小关节关节炎一起导致退行性腰椎滑脱。目前仍不完全清楚哪些因素会引发和影响椎间盘退变的进展。然而，人们普遍认为脊柱机械应力会加速椎间盘退变的发展，并增加椎间盘突出的可能性（4-6）。越来越多的证据表明，性激素也会影响椎间盘退变的严重程度。
