Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute (CNESPS), Istituto Superiore di Sanità (ISS), Rome, Italy.
Blood. 2011 Feb 10;117(6):1792-8. doi: 10.1182/blood-2010-06-275818. Epub 2010 Oct 19.
Over the past 2 decades considerable evidence has accumulated on the association between hepatitis C virus (HCV) and hepatitis B virus (HBV) and several hematologic malignancies, most notably B-cell non-Hodgkin lymphoma (NHL). In this review we summarize this evidence, address possible mechanisms whereby hepatitis viruses may contribute to lymphomagenesis, and discuss the therapeutic fallouts from this knowledge. Most of this evidence is on HCV, and this is the main focus of the review. Moreover, we mainly address the association with NHL, the most prevalent hematologic malignancy, and the most extensively investigated with regard to an association with hepatitis viruses. Available evidence on the association with other hematologic malignancies is also addressed briefly.
在过去的 20 年中，积累了相当多的证据表明丙型肝炎病毒（HCV）和乙型肝炎病毒（HBV）与几种血液系统恶性肿瘤有关，尤其是 B 细胞非霍奇金淋巴瘤（NHL）。在这篇综述中，我们总结了这些证据，探讨了肝炎病毒可能导致淋巴瘤发生的可能机制，并讨论了这方面知识的治疗意义。这些证据大部分是关于 HCV 的，这也是本综述的主要重点。此外，我们主要讨论了与 NHL 的关联，NHL 是最常见的血液系统恶性肿瘤，并且针对其与肝炎病毒的关联进行了最广泛的研究。也简要讨论了与其他血液系统恶性肿瘤相关的证据。
