H. Lee Moffitt Cancer and Research Institute, Division of Hematological Malignancies and the University of South Florida, Tampa, FL, USA.
Leuk Res. 2013 Sep;37(9):1107-15. doi: 10.1016/j.leukres.2013.06.007. Epub 2013 Jun 26.
Hepatitis B virus (HBV) infection is a major public health problem and the association between HBV infection and non-Hodgkin lymphoma (NHL) is unclear. The primary aim of our study was to evaluate the association between HBV infection assessed by a positive hepatitis B surface antigen (HBsAg) and the incidence of NHL and subtypes using a meta-analysis of epidemiological studies. The random effects model was used to calculate the outcome. Our search yielded 17 case-control and 5 cohort studies, including over 40,000 NHL cases. HBV infected individuals had an OR of 2.24 (95% CI 1.80-2.78; p ≤ 0.001) of developing NHL. In high HBV prevalent countries, there were increased odds of diffuse large B-cell lymphoma and a trend toward increased odds of developing follicular and T-cell lymphoma. Future research is needed to better understand the biological mechanisms responsible for lymphomagenesis in patients with HBV infection.
乙型肝炎病毒（HBV）感染是一个主要的公共卫生问题，HBV 感染与非霍奇金淋巴瘤（NHL）之间的关系尚不清楚。我们的研究主要目的是通过对流行病学研究的荟萃分析来评估乙型肝炎表面抗原（HBsAg）阳性的 HBV 感染与 NHL 发生率和亚型之间的关系。采用随机效应模型计算结果。我们的检索结果包括 17 项病例对照研究和 5 项队列研究，共涉及超过 40000 例 NHL 病例。HBV 感染者患 NHL 的比值比（OR）为 2.24（95%CI 1.80-2.78；p ≤ 0.001）。在 HBV 高发国家，弥漫性大 B 细胞淋巴瘤的发病几率增加，滤泡性和 T 细胞淋巴瘤的发病几率也有增加的趋势。需要进一步的研究来更好地理解 HBV 感染患者中负责淋巴瘤发生的生物学机制。
