Center for Diabetes and Endocrinology, Tazuke Kofukai Medical Research Institute Kitano Hospital, Kita-ku, Osaka, 530-8480, Japan.
Endocrine. 2010 Apr;37(2):286-8. doi: 10.1007/s12020-009-9301-0. Epub 2010 Jan 9.
We report consecutive Japanese patients presented with acute onset diabetic ketosis who had negative glutamic acid decarboxylase autoantibody (GADAb) to clarify the clinical characteristics of them. A total of consecutive 1,296 in-patients with newly diagnosed diabetes mellitus, who were admitted to our center from April 2003 to October 2008, were analyzed. Among them, 17 patients who presented with acute onset diabetic ketosis without acidosis, and found to be negative for GADAb, were included. They showed male preponderance (n = 15). Ten patients had history of excessive ingestion of sugar-containing soft drink. Patients who successfully withdrew insulin therapy by 6 months (n = 7) showed significantly higher insulin secretion capacity and higher body mass index at the time of diagnosis than those who continued insulin therapy at least for 6 months (n = 10). These findings suggest that some of Japanese patients who presented with acute onset diabetic ketosis and negative for GADAb share several clinical characteristics with atypical type 2 diabetes such as ketosis-prone diabetes and "soft-drink ketosis," but others do not.
我们报告了连续的日本患者出现急性发作的糖尿病酮症酸中毒，这些患者谷氨酸脱羧酶自身抗体（GADAb）阴性，以阐明他们的临床特征。总共分析了 2003 年 4 月至 2008 年 10 月期间因新发糖尿病而入住我院的连续 1296 例住院患者。其中，纳入了 17 例无酸中毒的急性发作糖尿病酮症酸中毒且 GADAb 阴性的患者。这些患者中男性居多（n=15）。10 例患者有过量摄入含糖软饮料的病史。在 6 个月时成功停用胰岛素治疗的 7 例患者（n=7）与至少继续胰岛素治疗 6 个月的 10 例患者（n=10）相比，胰岛素分泌能力更高，诊断时体重指数更高。这些发现表明，一些日本患者出现急性发作的糖尿病酮症酸中毒且 GADAb 阴性，与酮症倾向糖尿病和“软饮料酮症”等非典型 2 型糖尿病具有一些共同的临床特征，但也有一些不具有。
