Department of Endocrinology and Metabolism, The Affiliated Huai'an Hospital of Xuzhou Medical College, No. 62 South Huaihai Road, Huai'an, 223002, China.
Endocrine. 2012 Dec;42(3):570-6. doi: 10.1007/s12020-012-9652-9. Epub 2012 Mar 23.
Ischemia-modified albumin (IMA) levels have been advocated as a biomarker for evaluating the oxidative stress status. No data are showed on the potential role of IMA in type 1 diabetes (T1D). We aimed to establish the correlation among serum levels of IMA, C-reactive protein (CRP), and diabetic ketoacidosis (DKA) in patients with T1D. Fifty-seven patients with T1D, 27 patients with DKA, and 40 controls were enrolled. Serum IMA and CRP levels were measured and evaluated to distinguish from DKA. CRP and IMA levels were significantly elevated in patients with DKA at admission to the hospital compared to non-DKA and control subjects. CRP and IMA levels were higher in non-DKA patients than in controls. CRP, plasma glucose, and IMA levels were reduced after insulin treatment. Serum IMA levels were an independent risk marker for DKA (OR = 1.225, p = 0.002, 95 % CI: 1.076-1.394). Receiver operating characteristic curve analyses showed no difference in the areas under curve for serum IMA and CRP values. This study indicates that IMA and CRP levels were significantly correlated with DKA diagnosis. IMA can act as a biomarker that reflects the presence of DKA.
缺血修饰白蛋白（IMA）水平被认为是评估氧化应激状态的生物标志物。尚未有研究表明 IMA 在 1 型糖尿病（T1D）中的潜在作用。我们旨在确定 T1D 患者血清 IMA 水平与 C 反应蛋白（CRP）和糖尿病酮症酸中毒（DKA）之间的相关性。纳入了 57 名 T1D 患者、27 名 DKA 患者和 40 名对照组。测量并评估了血清 IMA 和 CRP 水平以与 DKA 区分。与非 DKA 和对照组相比，入院时 DKA 患者的 CRP 和 IMA 水平显着升高。非 DKA 患者的 CRP 和 IMA 水平高于对照组。胰岛素治疗后，CRP、血浆葡萄糖和 IMA 水平降低。血清 IMA 水平是 DKA 的独立危险因素（OR=1.225，p=0.002，95%CI：1.076-1.394）。受试者工作特征曲线分析表明，血清 IMA 和 CRP 值的曲线下面积没有差异。本研究表明，IMA 和 CRP 水平与 DKA 诊断显着相关。IMA 可以作为反映 DKA 存在的生物标志物。
