Department of Immunology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Endocrine. 2010 Apr;37(2):312-21. doi: 10.1007/s12020-009-9297-5. Epub 2010 Jan 9.
The growth and renewal of epithelial tissue is a highly orchestrated and tightly regulated process occurring in different tissue types under a variety of circumstances. We have been studying the process of pancreatic regeneration in mice. We have identified a cell surface protein, named EP1, which is expressed on the duct epithelium during pancreatic regeneration. Whereas it is not detected in the pancreas of normal mice, it is found in the intestinal epithelium of normal adult mice, as well as during pancreatic repair following cerulein-induced destruction of the acinar tissue. The distinctive situations in which EP1 is expressed, all of which share in common epithelial cell growth in the gastrointestinal tract, suggest that EP1 is involved in the growth and renewal of epithelial tissues in both the intestine and the pancreas.
上皮组织的生长和更新是一个高度协调和严格调控的过程，发生在不同类型的组织中，在各种情况下。我们一直在研究小鼠胰腺再生的过程。我们已经鉴定出一种细胞表面蛋白，命名为 EP1，它在胰腺再生期间表达于导管上皮。虽然在正常小鼠的胰腺中未检测到，但在正常成年小鼠的肠道上皮中以及在 cerulein 诱导的腺泡组织破坏后的胰腺修复过程中都发现了它的存在。EP1 表达的独特情况都与胃肠道上皮细胞的生长有关，这表明 EP1 参与了肠道和胰腺上皮组织的生长和更新。
