Inserm, Imagerie cérébrale et handicaps neurologiques, Toulouse, France.
Mov Disord. 2011 Jan;26(1):153-7. doi: 10.1002/mds.23406. Epub 2010 Oct 19.
Patients with Parkinson's disease (PD) frequently experience pain that could be in part due to central modification of nociception. In this randomized controlled double blind study, we compared the effect of apomorphine versus placebo on pain thresholds and pain-induced cerebral activity in 25 patients with PD. Subjective pain threshold (using thermal stimulation, thermotest), objective pain threshold (nociceptive flexion reflex), and cerebral activity (H(2)(15)O PET) during noxious and innocuous stimulations were performed. Neither subjective nor objective pain thresholds nor pain activation profile were modified by apomorphine compared with placebo in 25 PD patients. Apomorphine has no effect on pain processing in PD. We suggest that other monoamine systems than dopaminergic system could be involved.
帕金森病（PD）患者常伴有疼痛，其部分原因可能是伤害感受的中枢调节异常。在这项随机对照双盲研究中，我们比较了阿扑吗啡与安慰剂对 25 例 PD 患者疼痛阈值和痛觉刺激时大脑活动的影响。通过热刺激（thermotest）检测患者的主观痛觉阈值、利用伤害性屈反射检测客观痛觉阈值，以及通过 H(2)(15)O PET 检测痛觉刺激时的大脑活动。与安慰剂相比，阿扑吗啡并未改变 25 例 PD 患者的主观和客观痛觉阈值，也未改变痛觉刺激时的大脑活动模式。阿扑吗啡对 PD 患者的疼痛处理过程没有影响。我们推测，除了多巴胺系统之外，其他单胺系统也可能参与其中。
