Zhang Jincai, Xuan Dongying, Fan Weihua, Zhang Xiong, Dibart Serge, De Vizio William, Panagakos Foti, Zhang Yun-Po
Guangdong Provincial Stomatological Hospital, Guangzhou, China.
Compend Contin Educ Dent. 2010 Oct;31(8):624-9.
This study investigated the prevalence and severity of gingivitis and plaque in a representative Chinese population of adults.
Using the Loe-Silness gingivitis index (GI) and the modified Quigley-Hein plaque index (PULI), researchers examined 1143 patients from Guangzhou, Shenyang, and Nanjing for the presence of gingivitis and plaque. A two-tailed t-test was used to determine significant differences in the GI and PLI scores between gender and urban/rural areas. The data pertaining to study sites and age groups were compared using the Kruskal-Wallis one-way analysis of variances (ANOVA) by ranks. The correlation between GI/PLI and age was examined using the Pearson correlation coefficient. Age differences among three sites were analyzed with the one-way ANOVA.
The age and urban/rural compositions (mean age 42.2 years) paralleled the 2008 China census. The overall average and standard deviation of GI and PLI were 1.101 +/- 0.239 and 3.394 +/- 0.578, respectively. Age significantly correlated with GI and PLI (P < .0001). The PLI in males was significantly higher (P < .0001) than in females; however, no significant difference was noted between GI in males compared to females. Patients in rural areas showed a significantly higher GI and PLI (t = 7.723, P < .0001; t = 7.072, P < .0001) than those in urban ones.
Clinical trials evaluating a product's antigingivitis efficacy should recruit participants from a population that represents accurately the intended product users. Variables should include gender, race, age, and geography.
本研究调查了具有代表性的中国成年人群中牙龈炎和牙菌斑的患病率及严重程度。
研究人员使用洛-西勒氏牙龈炎指数(GI)和改良的奎格利-海因菌斑指数(PULI),对来自广州、沈阳和南京的1143名患者进行了牙龈炎和牙菌斑检查。采用双尾t检验确定性别和城乡地区之间GI和PLI评分的显著差异。使用Kruskal-Wallis秩次单向方差分析(ANOVA)比较与研究地点和年龄组相关的数据。使用Pearson相关系数检查GI/PLI与年龄之间的相关性。用单向ANOVA分析三个地点之间的年龄差异。
年龄和城乡构成(平均年龄42.2岁)与2008年中国人口普查情况相符。GI和PLI的总体平均值及标准差分别为1.101±0.239和3.394±0.578。年龄与GI和PLI显著相关(P<.0001)。男性的PLI显著高于女性(P<.0001);然而,男性与女性的GI之间未发现显著差异。农村地区患者的GI和PLI显著高于城市地区患者(t=7.723,P<.0001;t=7.072,P<.0001)。
评估产品抗牙龈炎疗效的临床试验应从能准确代表目标产品使用者的人群中招募参与者。变量应包括性别、种族、年龄和地理位置。