正常HLA A1 B8 DR3受试者中白细胞介素-2受体亲和力增加。

Increased interleukin-2 receptor affinity in normal HLA A1 B8 DR3 subjects.

作者信息

Pomier G, Vindimian M, Healy J C, Le Petit J C

机构信息

Laboratoire d'Immunologie C.H.R.U., Saint-Etienne, France.

出版信息

J Immunogenet. 1990 Dec;17(6):371-7. doi: 10.1111/j.1744-313x.1990.tb00888.x.

DOI:10.1111/j.1744-313x.1990.tb00888.x

PMID:2096181

Abstract

Twenty-two subjects (11 HLA A1 B8 DR3, 11 non-A1 B8 DR3) were tested for the capacity of their lymphocytes to express Tac molecules and interleukin-2 (IL-2) receptors (quantified using radiolabelled IL-2) after mitogen stimulation. Ten of these subjects (five A1 B8 DR3 and five non-A1 B8 DR3) were also tested for the ability of their lymphocytes to proliferate under IL-2 stimulation. A1 B8 DR3 subjects express a normal number of high-affinity IL-2 receptor sites, but the affinity of these receptors sites is significantly increased. Unexpectedly, A1 B8 DR3 lymphoblasts show a lower response to IL-2 than non-A1 B8 DR3 for high doses of recombinant IL-2.

摘要

对22名受试者（11名HLA A1 B8 DR3，11名非A1 B8 DR3）进行检测，观察其淋巴细胞在丝裂原刺激后表达Tac分子和白细胞介素-2（IL-2）受体的能力（使用放射性标记的IL-2进行定量）。其中10名受试者（5名A1 B8 DR3和5名非A1 B8 DR3）还接受了淋巴细胞在IL-2刺激下增殖能力的检测。A1 B8 DR3受试者表达的高亲和力IL-2受体位点数量正常，但这些受体位点的亲和力显著增加。出乎意料的是，对于高剂量的重组IL-2，A1 B8 DR3淋巴母细胞对IL-2的反应低于非A1 B8 DR3。