The Methodist Hospital, Houston, TX 77030, USA.
J Antimicrob Chemother. 2010 Dec;65(12):2489-92. doi: 10.1093/jac/dkq389. Epub 2010 Oct 20.
Progressive multifocal leukoencephalopathy is a neurological disease caused by the human polyoma virus JC virus and can present in patients with known immunodeficiencies. However, when associated with idiopathic CD4+ lymphocytopenia, management of patients can be quite challenging as these are two rare diseases with limited effective treatment options. In conjunction with the case report of a patient diagnosed with both conditions presented within this issue, a discussion of available treatment strategies is detailed.
进行性多灶性白质脑病是一种由人类多瘤病毒 JC 病毒引起的神经系统疾病，可发生于已知免疫缺陷的患者中。然而，当与特发性 CD4+淋巴细胞减少症相关时，患者的管理可能极具挑战性，因为这两种疾病都很罕见，且有效治疗选择有限。结合本期发表的一例同时诊断出这两种疾病的患者病例报告，详细讨论了现有的治疗策略。
