Arushanian E B, Baturin V A, Ovanesov K B
Department of Pharmacology, Medical Institute, Stavropol, U.S.S.R.
J Pineal Res. 1990;9(4):271-7. doi: 10.1111/j.1600-079x.1990.tb00902.x.
After chronic administration of epithalamin (a pineal peptide drug), an increase in the amplitude and shifts in the acrophase of rat's circadian locomotor activity to late hours were observed. These results were obtained only in rats with low initial amplitude of their circadian rhythm. Epithalamin also changed the time-course of forced swimming and decreased the rhythmic index of depression. These observations suggest that the pineal gland of the rat, via its peptides, may prevent the development of depressive-like events.
长期给予epithalamin（一种松果体肽药物）后，观察到大鼠昼夜节律性运动活动的振幅增加，且其活动高峰期相位后移至较晚时间。这些结果仅在昼夜节律初始振幅较低的大鼠中获得。Epithalamin还改变了强迫游泳的时间进程，并降低了抑郁的节律指数。这些观察结果表明，大鼠的松果体可能通过其分泌的肽来预防类似抑郁事件的发生。
