膳食中的苯并[a]芘摄入与结直肠癌风险。
Dietary benzo[a]pyrene intake from meat and the risk of colorectal cancer.
机构信息
School of Population Health, The University of Western Australia, Nedlands, Western Australia, Australia.
出版信息
Cancer Epidemiol Biomarkers Prev. 2010 Dec;19(12):3182-4. doi: 10.1158/1055-9965.EPI-10-1051. Epub 2010 Oct 20.
INTRODUCTION
One possible mechanism for the postulated link between high consumption of meat and colorectal cancer (CRC) is the content of benzo[a]pyrene (BaP) in meat.
METHODS
We investigated this association in a population-based case-control study in Western Australia (567 cases and 713 controls). Participants' self-report of meat consumption and lifestyle was used in conjunction with the CHARRED carcinogen database to estimate their BaP intake.
RESULTS
Dietary exposure to BaP from meat consumption was not associated with the risk of CRC.
CONCLUSIONS
Our findings do not support the hypothesis that BaP exposure from meat consumption is a risk factor for CRC. IMPACT STATEMENT: This large-scale case-control study used a detailed meat questionnaire in conjunction with the CHARRED database in a large population with high meat intake but was unable to find any association between intake of BaP and colorectal cancer.
简介
高肉类摄入量与结直肠癌（CRC）之间假定关联的一个可能机制是肉类中苯并[a]芘（BaP）的含量。
方法
我们在澳大利亚西部进行了一项基于人群的病例对照研究（567 例病例和 713 例对照），调查了这种相关性。参与者自我报告的肉类消费和生活方式与 CHARRED 致癌物数据库结合使用，以估计他们的 BaP 摄入量。
结果
饮食中 BaP 暴露于肉类消费与 CRC 风险无关。
结论
我们的研究结果不支持肉类消费中 BaP 暴露是 CRC 危险因素的假设。
影响说明
这项大规模的病例对照研究使用详细的肉类问卷，并结合 CHARRED 数据库，在肉类摄入量高的人群中进行，但未能发现 BaP 摄入与结直肠癌之间存在任何关联。
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