钴催化的分子内 C-N 和 C-O 交叉偶联反应：苯并咪唑和苯并恶唑的合成。

Cobalt-catalyzed intramolecular C-N and C-O cross-coupling reactions: synthesis of benzimidazoles and benzoxazoles.

机构信息

Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati-781039, India.

出版信息

Org Biomol Chem. 2010 Dec 21;8(24):5692-9. doi: 10.1039/c0ob00405g. Epub 2010 Oct 20.

PMID:20963217

Abstract

Cobalt(ii)-complex catalyzes efficiently the intramolecular C-N and C-O cross-couplings of Z-N'-(2-halophenyl)-N-phenylamidines and N-(2-bromophenyl)benzamides to afford the corresponding substituted benzimidazoles and benzoxazoles in the presence of K(2)CO(3) at moderate temperature. The protocol is general, air stable and affords the products selectively in moderate to high yield.

摘要

钴(ii)配合物能高效地催化 Z-N'-(2-卤代苯基)-N-苯基脒和 N-(2-溴苯基)苯甲酰胺的分子内 C-N 和 C-O 交叉偶联反应，在 K2CO3 的存在下，于中等温度下得到相应的取代苯并咪唑和苯并恶唑。该反应条件温和、空气稳定、产物选择性好、收率适中到较高。