Reis de Oliveria I, Diquet B, Van der Meersch V, Dardennes R, Gonidec J, do Prado-Lima P A
Clinique des Maladies Mentales et de l'Encéphale, Paris, France.
Psychopharmacology (Berl). 1990;102(4):553-6. doi: 10.1007/BF02247141.
Animals were treated acutely with 0, 2.5, 5, 10, 20 and 40 mg/kg nortriptyline (NT) 30 min before the tail suspension test (TST). They were sacrificed after test for evaluation of plasma and brain levels of NT. The anti-immobility effect increased with increasing doses and concentrations of the drug, reaching statistical significance (P less than 0.01, Dunnett test) at a dose of 20 mg/kg, 865 ng/ml in plasma and 11 micrograms/g in brain tissue. The anti-immobility effect was, however, blocked with the highest, non-toxic, concentrations. Results seem to indicate a biphasic curvilinear relationship between plasma and brain levels of NT and behaviour in mice.
在进行悬尾实验（TST）前30分钟，给动物急性注射0、2.5、5、10、20和40毫克/千克的去甲替林（NT）。实验结束后将它们处死，以评估血浆和脑组织中NT的水平。随着药物剂量和浓度的增加，抗不动效应增强，在剂量为20毫克/千克时达到统计学显著性（P小于0.01，Dunnett检验），此时血浆中浓度为865纳克/毫升，脑组织中浓度为11微克/克。然而，最高的无毒浓度会阻断抗不动效应。结果似乎表明小鼠血浆和脑组织中NT水平与行为之间存在双相曲线关系。
