Poncelet M, Gaudel G, Danti S, Soubrié P, Simon P
Psychopharmacology (Berl). 1986;90(1):139-41. doi: 10.1007/BF00172885.
Immobility scores in the swimming test and brain concentrations of desipramine were determined in rats and mice following repeated injection of the antidepressant versus acute administration of either a behaviorally effective or ineffective dose of the drug. Five injections (IP) of desipramine (each injection being performed at the measured T1/2 of the drug in the brain) reduced immobility scores by 30%, whereas this regimen resulted in brain drug concentrations not different from those obtained after a single, behaviorally ineffective dose of desipramine. It is suggested that the enhanced "antidepressant" response such as that frequently observed in animals after repeated injection of imipramine-like drugs does not involve accumulation of the drug in the brain.
在大鼠和小鼠中，在反复注射抗抑郁药后，与急性给予行为有效或无效剂量的药物相比，测定了游泳试验中的不动性评分和地昔帕明的脑浓度。五次腹腔注射地昔帕明（每次注射在脑中药物的实测半衰期时进行）可使不动性评分降低30%，而该方案导致的脑药物浓度与单次给予行为无效剂量的地昔帕明后获得的浓度无差异。有人提出，反复注射丙咪嗪类药物后动物中经常观察到的增强的“抗抑郁”反应并不涉及药物在脑中的蓄积。
