Stolerman I P, Mariathasan E A
Department of Psychiatry, Institute of Psychiatry, De Crespigny Park, London, UK.
Psychopharmacology (Berl). 1990;102(4):557-60. doi: 10.1007/BF02247142.
Rats were trained to discriminate a mixture of amphetamine plus pentobarbitone from either drug separately in a two-bar procedure with food reinforcement. Discrimination was 86% accurate after 48 sessions, and no dose of amphetamine or pentobarbitone alone produced mixture-appropriate responding. Some mixtures increased response rates whereas the same doses of each drug separately had little effect. The same rats were then trained to discriminate a mixture from saline. There was a continuing lack of discriminative response to amphetamine and only a partial response to pentobarbitone, and under these conditions mixtures did not increase overall response rates. Thus, the way rats are trained, and their previous history, can determine the characteristics of the cue obtained.
在一个双杆程序中，通过食物强化训练大鼠区分苯丙胺加戊巴比妥的混合物与单独的两种药物。48次训练后辨别准确率达86%，单独使用任何剂量的苯丙胺或戊巴比妥都不会产生与混合物相应的反应。一些混合物会提高反应率，而相同剂量的每种药物单独使用时几乎没有效果。然后对相同的大鼠进行训练，使其区分混合物和生理盐水。大鼠对苯丙胺持续缺乏辨别反应，对戊巴比妥只有部分反应，在这些条件下，混合物不会提高总体反应率。因此，大鼠的训练方式及其既往经历可以决定所获得线索的特征。
