Koek W, Slangen J L
Psychopharmacology (Berl). 1982;76(2):149-56. doi: 10.1007/BF00435269.
Different groups of rats were trained to discriminate fentanyl (F) (0.03, 0.02, or 0.01 mg/kg) from saline or to discriminate 0.03 mg/kg fentanyl (F) from alternative stimulus conditions (saline, 0.15 mg/kg nicotine, or 0.01 mg/kg F). When percentage of responses on the drug lever and percentage of time spent responding on the drug lever were used as dependent variables, it was found that training dose and alternative stimulus condition both affected the ED50 and the slope of the F generalization gradient. ED50 and slope values based on group data were not significantly different from values based on individual data. Differences between from values based on individual data. Differences between the results of the first and second 2.5-min period of the extinction test were not significant. ED50 and slope values were unaffected by the preceding training session, except in the group trained to discriminate 0.03 from 0.01 mg/kg F. A lever selection measure showed a significant effect of alternative stimulus condition on ED50 values only. Training dose and alternative stimulus condition also affected the generalization to morphine. Under none of the conditions explored in this study did generalization occur to amphetamine or nicotine. The results are discussed in terms of the relative nature of drug generalization.
将不同组的大鼠训练成能够区分芬太尼（F）（0.03、0.02或0.01毫克/千克）与生理盐水，或者区分0.03毫克/千克芬太尼（F）与其他刺激条件（生理盐水、0.15毫克/千克尼古丁或0.01毫克/千克F）。当将药物杠杆上的反应百分比和在药物杠杆上反应所花费的时间百分比用作因变量时，发现训练剂量和替代刺激条件均会影响ED50以及芬太尼泛化梯度的斜率。基于组数据的ED50和斜率值与基于个体数据的值无显著差异。消退测试的第一个和第二个2.5分钟时间段结果之间的差异不显著。ED50和斜率值不受之前训练环节的影响，但在训练区分0.03与0.01毫克/千克F的组中除外。一种杠杆选择测量方法显示，替代刺激条件仅对ED50值有显著影响。训练剂量和替代刺激条件也会影响对吗啡的泛化。在本研究探索的任何条件下，均未出现对苯丙胺或尼古丁的泛化。将根据药物泛化的相对性质对结果进行讨论。
