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粒子治疗中的快速重扫和门控移动目标照射。

Moving target irradiation with fast rescanning and gating in particle therapy.

机构信息

Medical Physics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.

出版信息

Med Phys. 2010 Sep;37(9):4874-9. doi: 10.1118/1.3481512.

Abstract

PURPOSE

In moving target irradiation with pencil beam scanning, the interplay effect between the target motion and the scanned beam is a problem because this effect causes over or under dosage in the target volume. To overcome this, we have studied rescanning using a gating technique.

METHODS

A simulation and experimental study was carried out. In the experiment, we used the fast scanning system developed at the HIMAC to verify the validity of phase controlled rescanning method, in which the time for rescanning irradiation of each slice is matched to the gating duration.

RESULTS

Simulation and experimental results showed that controlling the scan speed to match the respiration cycle with rescans can deliver the blurred dose distribution. In the comparison between the static measurements and the moving measurements with the phase controlled rescanning method, the dose difference was less than 2% for pinpoint chambers in the target volume.

CONCLUSIONS

The simulation and experimental results demonstrated that the phase controlled rescanning method makes it possible to deliver the dose distribution close to the expected one. As an experimental result for 3D irradiation, it was estimated that blurring by the probability density function was not only for a lateral distribution, but also for a distal distribution, even in the lateral rescanning.

摘要

目的

在笔形束扫描的移动目标照射中,目标运动和扫描束之间的相互作用是一个问题,因为这种相互作用会导致目标体积中的剂量过高或过低。为了克服这个问题,我们研究了使用门控技术进行重扫描。

方法

进行了模拟和实验研究。在实验中,我们使用 HIMAC 开发的快速扫描系统验证了相位控制重扫描方法的有效性,其中每个切片的重扫描照射时间与门控持续时间匹配。

结果

模拟和实验结果表明,控制扫描速度以匹配呼吸周期的重扫描可以提供模糊的剂量分布。在静态测量和相位控制重扫描方法的移动测量之间的比较中,在目标体积中的点剂量室中,剂量差异小于 2%。

结论

模拟和实验结果表明,相位控制重扫描方法可以实现接近预期的剂量分布。作为 3D 照射的实验结果,可以估计概率密度函数的模糊不仅发生在横向分布,而且发生在远端分布,即使在横向重扫描中也是如此。

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