Feraille E, Krempf M, Charbonnel B, Bouhour J B, Nicolas G
Laboratoire de Physiologie Cellulaire, Collège de France, Paris.
Rev Med Interne. 1990 Jul-Aug;11(4):293-6. doi: 10.1016/s0248-8663(05)80861-6.
The association between arterial hypertension and obesity has been known for many years and demonstrated by epidemiological studies. The physiopathological mechanisms involved consist of increased extracellular volumes, hyperactivity of the sympathetic nervous system and the renin-angiotensin-aldosterone system, and abnormal ion exchanges between extra- and intracellular compartments. Recent studies have demonstrated an association between arterial hypertension and insulin resistance. Insulin resistance may well be the most important aetiological factor in this type of arterial hypertension as it stimulates both renal sodium reabsorption and sympathetic nervous system activity and reduces vascular Na-K-ATPase activity.
动脉高血压与肥胖之间的关联已为人所知多年，并经流行病学研究证实。其中涉及的生理病理机制包括细胞外液量增加、交感神经系统及肾素 - 血管紧张素 - 醛固酮系统活性亢进，以及细胞内外 compartments 之间异常的离子交换。最近的研究表明动脉高血压与胰岛素抵抗之间存在关联。胰岛素抵抗很可能是这类动脉高血压最重要的病因学因素，因为它既刺激肾钠重吸收和交感神经系统活性，又降低血管钠钾ATP酶活性。
