Adis, a Wolters Kluwer Business, Auckland, New Zealand.
Drugs. 2010 Nov 12;70(16):2113-20. doi: 10.2165/11206390-000000000-00000.
The lidocaine/tetracaine medicated plaster comprises a lidocaine/tetracaine 70 mg/70 mg patch and a controlled heat-assisted drug delivery pod that increases the diffusion of lidocaine and tetracaine into the dermis. Following a 1-hour application period, systemic absorption of lidocaine or tetracaine from the plaster was minimal. The lidocaine/tetracaine medicated plaster provided effective pain relief for adult (including elderly) patients undergoing minor dermatological procedures and for adult and paediatric patients undergoing vascular access procedures. In randomized, double-blind clinical trials, patient-reported median pain scores were significantly lower with the lidocaine/tetracaine medicated plaster than with an identical plaster containing placebo in patients undergoing minor dermatological or vascular access procedures. Furthermore, patient-reported median pain scores were significantly lower with the lidocaine/tetracaine medicated plaster than with a lidocaine/prilocaine cream in patients undergoing vascular access procedures. In a large, randomized, double-blind trial in paediatric patients undergoing venipuncture, the overall incidence of pain was significantly lower with the lidocaine/tetracaine medicated plaster than with a lidocaine/prilocaine plaster. The lidocaine/tetracaine medicated plaster was well tolerated, with the most frequent treatment-related adverse events resolving spontaneously.
利多卡因/丁卡因贴膏由一片含 70mg 利多卡因和 70mg 丁卡因的贴膏和一个控制加热辅助药物输送小袋组成，该小袋可增加利多卡因和丁卡因向真皮的扩散。贴膏使用 1 小时后，利多卡因或丁卡因的全身吸收很少。利多卡因/丁卡因贴膏为接受小型皮肤科手术的成年（包括老年）患者以及接受血管通路手术的成年和儿科患者提供了有效的疼痛缓解。在随机、双盲临床试验中，与含有安慰剂的相同贴膏相比，接受小型皮肤科或血管通路手术的患者报告的中位数疼痛评分显著更低。此外，与接受血管通路手术的患者使用利多卡因/丙胺卡因乳膏相比，接受利多卡因/丁卡因贴膏的患者报告的中位数疼痛评分显著更低。在一项大型、随机、双盲的儿科患者静脉穿刺试验中，与使用利多卡因/丙胺卡因贴膏相比，利多卡因/丁卡因贴膏的总体疼痛发生率显著更低。利多卡因/丁卡因贴膏耐受性良好，最常见的治疗相关不良事件可自行缓解。
