Department of Radiation Oncology, University of California San Francisco, Helen Diller Family Cancer Center, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94143-1708, USA.
Expert Rev Mol Diagn. 2010 Oct;10(7):883-95. doi: 10.1586/erm.10.76.
Neoplasms of the hepatobiliary system include primary tumors, such as hepatocellular carcinoma and cholangiocarcinoma, and secondary lesions from the metastatic spread of a cancer of nonhepatobiliary origin. Surgical excision remains the mainstay of long-term survival for primary tumors whereas secondary lesions can be treated by multiple modalities, including resection, radiotherapy and radiofrequency ablation. However, diagnosis of hepatobiliary neoplasms often occurs late in the disease process. In this article we will focus on the diagnostic approaches and new molecular diagnostics of primary hepatobiliary cancers and we will discuss how these new developments may impact the detection and management of these recalcitrant cancers.
肝胆系统肿瘤包括原发性肿瘤，如肝细胞癌和胆管癌，以及非肝胆来源的癌症转移引起的继发性病变。手术切除仍然是原发性肿瘤长期生存的主要方法，而继发性病变可以通过多种方法治疗，包括切除、放疗和射频消融。然而，肝胆肿瘤的诊断通常在疾病过程的晚期才出现。本文将重点介绍原发性肝胆癌的诊断方法和新的分子诊断方法，并讨论这些新进展如何影响这些难治性癌症的检测和治疗。
