Institut für Integrative Biologie, ETH, Universitätstrasse 16, Zürich, Switzerland.
J Evol Biol. 2010 Dec;23(12):2625-35. doi: 10.1111/j.1420-9101.2010.02139.x. Epub 2010 Oct 21.
A virus infecting a host faces a heterogeneous and a spatially structured environment. Using a mathematical model that incorporates two types of target cells and spatial structuring, we investigate conditions for viral within-host diversification. We show that branching occurs for a wide range of parameters but that it always requires some spatial structure. Applying our model to the case of HIV, we show that it captures three main properties of the 'co-receptor switch' observed in many HIV infections: the initial dominance of virus strains that infect CCR5(+) cells, the late switch in some (but, importantly, not all) HIV infections and the associated drop in the number of uninfected T-cells. This suggests that the co-receptor switch could result from gradual adaptation of the virus population to target cell heterogeneity. More generally, we argue that evolutionary ecology can help us better understand the course of some infections.
感染宿主的病毒面临着异质和空间结构的环境。我们使用了一个包含两种类型靶细胞和空间结构的数学模型，研究了病毒在宿主内多样化的条件。我们表明，分支发生在广泛的参数范围内，但它始终需要一些空间结构。将我们的模型应用于 HIV 的情况，我们表明它捕捉到了在许多 HIV 感染中观察到的“共受体转换”的三个主要特性：最初占主导地位的是感染 CCR5(+)细胞的病毒株，在某些（但重要的是，不是所有）HIV 感染中晚期的转换，以及与之相关的未感染 T 细胞数量的下降。这表明共受体转换可能是病毒种群对靶细胞异质性的逐渐适应的结果。更一般地，我们认为进化生态学可以帮助我们更好地理解一些感染的过程。
