听力测定作为疟疾治疗期间奎宁血浆浓度的一种可能指标。

Audiometry as a possible indicator of quinine plasma concentration during treatment of malaria.

作者信息

Karlsson K K, Hellgren U, Alván G, Rombo L

机构信息

Department of Audiology, Huddinge University Hospital, Sweden.

出版信息

Trans R Soc Trop Med Hyg. 1990 Nov-Dec;84(6):765-7. doi: 10.1016/0035-9203(90)90069-q.

DOI:10.1016/0035-9203(90)90069-q

PMID:2096500

Abstract

The spread of chloroquine-resistant malaria has led to a resurgence of quinine in clinical use. One of the well-known side effects of quinine, reversible hearing loss, is closely related to the plasma concentration. We suggest that this hearing effect could be used as an aid in therapy control when quinine drug assay is not available.

摘要

氯喹耐药性疟疾的传播导致了奎宁在临床应用中的再度兴起。奎宁的一个众所周知的副作用——可逆性听力丧失，与血浆浓度密切相关。我们认为，当无法进行奎宁药物检测时，这种听力影响可用于辅助治疗控制。