Child Health and Development Studies, The Public Health Institute, Berkeley, CA 94709, United States.
Reprod Toxicol. 2011 Apr;31(3):302-11. doi: 10.1016/j.reprotox.2010.10.004. Epub 2010 Oct 19.
More than 20 studies of serum "DDT" and breast cancer have found little support for the hypothesis that exposure influences risk of breast cancer. However, studies share common limitations including the inability to account for exposure in early life when the breast may be most vulnerable and the inability to measure exposure to the primary components of commercial DDT. This paper (1) summarizes evidence regarding critical windows of exposure for breast cancer (2) summarizes lessons learned from initial efforts to study DDT and breast cancer (3) reviews evidence from the Child Health and Development Studies (CHDS) where exposure was measured in young women using blood samples obtained during active exposure, 1-3 days after delivery and (4) suggests approaches for human studies that might advance understanding of environmental stressors in the developmental origins of disease.
已有 20 多项关于血清“DDT”与乳腺癌的研究，几乎没有发现支持接触 DDT 会影响乳腺癌风险这一假说的证据。然而，这些研究存在共同的局限性，包括无法解释生命早期（乳房可能最脆弱的时期）的接触情况，也无法测量商业 DDT 的主要成分的接触情况。本文（1）总结了乳腺癌暴露关键期的相关证据，（2）总结了最初研究 DDT 与乳腺癌工作中汲取的经验教训，（3）回顾了“儿童健康与发展研究（CHDS）”的证据，该研究在女性分娩后 1-3 天处于活跃暴露期间，通过血液样本测量了她们的接触情况，（4）提出了可能有助于了解疾病发展过程中环境应激源的人类研究方法。
