Martinova Y S, Nikolova D B
Institute of Cell Biology and Morphology, Bulgarian Academy of Sciences, Sofia.
Z Mikrosk Anat Forsch. 1990;104(6):969-74.
Single doses of anticancer drug biocarbazine (BC)--DTIC synonym--were injected intraperitoneally at 50 and 200 mg/kg body weight to sexually mature BALB/c mice. Among other features previously reported (Martinova et al. 1989) BC causes ultrastructural alterations in spermatogonia and spermatocytes significantly expressed after administration of higher dose. In addition BC induces some defects in acrosome formation of early spermatids in Golgi and cap phase, while spermatids in later stages of maturation showed marked resistance to BC treatment.
将单剂量的抗癌药物生物卡巴嗪（BC）——达卡巴嗪的同义词——以50毫克/千克和200毫克/千克体重的剂量腹腔注射给性成熟的BALB/c小鼠。如先前报道的其他特征（Martinova等人，1989年）所示，BC会导致精原细胞和精母细胞的超微结构改变，在给予较高剂量后这种改变会显著表现出来。此外，BC会在高尔基体期和顶帽期诱导早期精子细胞的顶体形成出现一些缺陷，而处于成熟后期的精子细胞对BC处理表现出明显的抗性。
