Martinova Y S, Nikolova D B, Michova Z
Z Mikrosk Anat Forsch. 1989;103(3):431-6.
Biocarbazin (DTIC synonym) is an anticancer drug acting as a purine analogue, as an alkylating agent, as a SH-group blocker. Biocarbazin administration in doses 50 and 200 mg/kg of body weight to adult male BALB/c mice suppresses the process of spermatogenesis. Seminiferous tubule of the testis displayed dose-dependent histological alterations manifested with decrease of mitotically dividing cells and increase in the number of multinucleated spermatocytes and spermatids. RNA synthetic activity studied by means of autoradiography showed a tendency for a reduction in the spermatogonia and pachytene spermatocytes.
生物卡巴嗪（达卡巴嗪的同义词）是一种抗癌药物，具有嘌呤类似物、烷基化剂和巯基阻断剂的作用。对成年雄性BALB/c小鼠按50和200毫克/千克体重的剂量给予生物卡巴嗪，可抑制精子发生过程。睾丸的生精小管呈现出剂量依赖性的组织学改变，表现为有丝分裂细胞减少，多核精母细胞和精子细胞数量增加。通过放射自显影研究的RNA合成活性显示，精原细胞和粗线期精母细胞有减少的趋势。
