透明质酸酶改变大鼠子宫颈的生物力学特性，并缩短产程而不影响子宫肌的收缩力。

Hyaluronidase modifies the biomechanical properties of the rat cervix and shortens the duration of labor independent of myometrial contractility.

机构信息

Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, The University of Texas Medical Branch, Galveston, TX, USA.

出版信息

Am J Obstet Gynecol. 2010 Dec;203(6):596.e1-5. doi: 10.1016/j.ajog.2010.07.031. Epub 2010 Oct 20.

DOI:10.1016/j.ajog.2010.07.031

PMID:20965489

Abstract

OBJECTIVE

To investigate the effect of intracervical hyaluronidase on the biomechanical properties of the cervix and on uterine contractility.

STUDY DESIGN

Sprague-Dawley rats (n = 33, term day 22) were injected with hyaluronidase (100 IU) or saline solution on day 18 of gestation (n = 8-9/group). On day 21, labor was induced with mifepristone (8 mg/rat). Injection-to-delivery times were recorded. Biomechanical properties of the cervix were assessed using stretch-tension analysis. Myometrial contractility was investigated in response to hyaluronidase (0.2-200 IU/mL), oxytocin (10(-10)M to 10(-5)M), and potassium chloride (60 mM).

RESULTS

Delivery times were shorter in the hyaluronidase group (P = .03). Cervices of the treated animals showed higher measures of elasticity and plasticity (P = .02 for both). Myometrial sensitivity to hyaluronidase, oxytocin, or potassium chloride was not affected by the cervical application of hyaluronidase (P > .05 for all).

CONCLUSION

Cervical hyaluronidase treatment shortens labor and alters the biomechanical properties of the cervix, independent of the myometrium.

摘要

目的

研究宫颈透明质酸酶对宫颈生物力学特性和子宫收缩力的影响。

研究设计

妊娠第 18 天，向 Sprague-Dawley 大鼠（n = 33，足月第 22 天）注射透明质酸酶（100 IU）或生理盐水（n = 8-9/组）。第 21 天，用米非司酮（8 mg/只）诱导分娩。记录注射到分娩的时间。采用拉伸张力分析评估宫颈的生物力学特性。研究透明质酸酶（0.2-200 IU/mL）、催产素（10（-10）M 至 10（-5）M）和氯化钾（60 mM）对子宫收缩力的影响。