青少年多囊卵巢综合征患者 CYP1A1 多态性。

CYP1A1 polymorphism in adolescents with polycystic ovary syndrome.

机构信息

Department of Pediatrics, Division of Adolescent Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey.

出版信息

Int J Gynaecol Obstet. 2011 Jan;112(1):8-10. doi: 10.1016/j.ijgo.2010.07.032. Epub 2010 Oct 20.

DOI:10.1016/j.ijgo.2010.07.032

PMID:20965504

Abstract

OBJECTIVE

To evaluate the rates of the CYP1A1 Ile/Val polymorphism in Turkish adolescent females.

METHODS

The CYP1A1 Ile/Val polymorphism was analyzed by collecting DNA samples from 44 adolescents with polycystic ovary syndrome (PCOS)--according to the Rotterdam criteria--and 120 healthy female controls aged 13-18 years in Ankara, Turkey.

RESULTS

There was a 2.5-fold increase in the frequency of the CYP1A1 Ile/Val genotype in adolescents with PCOS compared with the control group (odds ratio [OR] 2.54; 95% confidence interval [CI], 1.143-5.637; P<0.001), in addition to a 2.4-fold increase in the frequency of the Val allele (OR 2.43; 95% CI, 1.099-5.397; P<0.001).

CONCLUSION

The data show an association between CYP1A1 and PCOS, indicating that variant alleles of the gene may affect the metabolic and transport pathway of estrogens, thus causing PCOS.

摘要

目的

评估 CYP1A1Ile/Val 多态性在土耳其青春期女性中的发生率。

方法

通过收集来自安卡拉的 44 名多囊卵巢综合征（PCOS）青少年（根据鹿特丹标准）和 120 名年龄在 13-18 岁的健康女性对照者的 DNA 样本，分析 CYP1A1Ile/Val 多态性。

结果

与对照组相比，患有 PCOS 的青少年 CYP1A1Ile/Val 基因型的频率增加了 2.5 倍（比值比[OR]2.54；95%置信区间[CI]1.143-5.637；P<0.001），Val 等位基因的频率也增加了 2.4 倍（OR 2.43；95%CI1.099-5.397；P<0.001）。