Department of Pediatrics, Division of Adolescent Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Int J Gynaecol Obstet. 2011 Jan;112(1):8-10. doi: 10.1016/j.ijgo.2010.07.032. Epub 2010 Oct 20.
To evaluate the rates of the CYP1A1 Ile/Val polymorphism in Turkish adolescent females.
The CYP1A1 Ile/Val polymorphism was analyzed by collecting DNA samples from 44 adolescents with polycystic ovary syndrome (PCOS)--according to the Rotterdam criteria--and 120 healthy female controls aged 13-18 years in Ankara, Turkey.
There was a 2.5-fold increase in the frequency of the CYP1A1 Ile/Val genotype in adolescents with PCOS compared with the control group (odds ratio [OR] 2.54; 95% confidence interval [CI], 1.143-5.637; P<0.001), in addition to a 2.4-fold increase in the frequency of the Val allele (OR 2.43; 95% CI, 1.099-5.397; P<0.001).
The data show an association between CYP1A1 and PCOS, indicating that variant alleles of the gene may affect the metabolic and transport pathway of estrogens, thus causing PCOS.
评估 CYP1A1Ile/Val 多态性在土耳其青春期女性中的发生率。
通过收集来自安卡拉的 44 名多囊卵巢综合征（PCOS）青少年（根据鹿特丹标准）和 120 名年龄在 13-18 岁的健康女性对照者的 DNA 样本，分析 CYP1A1Ile/Val 多态性。
与对照组相比，患有 PCOS 的青少年 CYP1A1Ile/Val 基因型的频率增加了 2.5 倍（比值比[OR]2.54；95%置信区间[CI]1.143-5.637；P<0.001），Val 等位基因的频率也增加了 2.4 倍（OR 2.43；95%CI1.099-5.397；P<0.001）。
数据显示 CYP1A1 与 PCOS 之间存在关联，表明该基因的变异等位基因可能影响雌激素的代谢和转运途径，从而导致 PCOS。
