Dai Li-ping, Wang Yan-ping, Wu Xiao-bing, Wang Kai-juan, Lv Quan-jun
College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2009 Nov;30(11):1198-202.
To examine the association between CYP1A1 polymorphisms (MspI and Ile/Val) and esophageal cancer (EC) by systematically reviewing the risk of the original studies.
Data from 16 papers (8 for MspI, 14 for Ile/Val) regarding case-control studies on the association of cytochrome P450 polymorphisms and risk of esophageal cancer was analyzed by dominant model (variant genotype vs. wild-type genotype) through meta-analysis. Stratified analysis was carried out according to the pathological types.
In systematical analysis, CYP1A1 MspI variant genotype (TC + CC) had no association with EC risk (OR = 1.17, 95%CI: 0.82 - 1.66). Similar results were observed in esophageal squamous-cell carcinoma (ESCC) (OR = 1.17, 95%CI: 0.82 - 1.69) and esophageal adenocarcinoma (EAC) (OR = 1.39, 95%CI: 0.67 - 2.09). Individuals with the CYP1A1 Ile/Val variant genotype (Ile/Val + Val/Val) had an increased risk for EC, when comparing with wild type (Ile/Ile), with an OR of 1.39 (95%CI: 1.07 - 1.80). CYP1A1 Ile/Val variant genotype could increase the risk of ESCC (OR = 1.43, 95%CI: 1.07 - 1.91) but no significant association was found with EAC (OR = 1.20, 95%CI: 0.62 - 2.30).
CYP1A1 gene polymorphism Ile/Val might have played a role in the development of ESCC but CYP1A1 MspI polymorphism might not be associated with the susceptibility of EC.
通过系统回顾原始研究的风险，探讨细胞色素P450 1A1（CYP1A1）基因多态性（MspI和Ile/Val）与食管癌（EC）之间的关联。
通过对16篇论文（8篇关于MspI，14篇关于Ile/Val）中有关细胞色素P450基因多态性与食管癌风险关联的病例对照研究数据，采用显性模型（变异基因型与野生型基因型）进行荟萃分析。根据病理类型进行分层分析。
在系统分析中，CYP1A1 MspI变异基因型（TC + CC）与食管癌风险无关（比值比[OR]=1.17，95%置信区间[CI]：0.82 - 1.66）。在食管鳞状细胞癌（ESCC）（OR = 1.17，95%CI：0.82 - 1.69）和食管腺癌（EAC）（OR = 1.39，95%CI：0.67 - 2.09）中观察到类似结果。与野生型（Ile/Ile）相比，CYP1A1 Ile/Val变异基因型（Ile/Val + Val/Val）个体患食管癌的风险增加，OR为1.3
