Dept. of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands.
Diabetes Res Clin Pract. 2011 Jan;91(1):32-9. doi: 10.1016/j.diabres.2010.09.030. Epub 2010 Oct 20.
We evaluated the associations of diabetic complications and underlying pathology with daily walking activity in type 2 diabetic patients without manifest mobility limitations.
100 persons with type 2 diabetes (mean age 64.5 ± 9.4 years) were studied. Persons with manifest mobility limitations were excluded. Possible determinants measured: peripheral neuropathy, neuropathic pain, peripheral arterial disease, cardiovascular disease, decreased muscle strength (handgrip strength), BMI, depression, falls and fear of falling. Walking activity was measured during one week with a pedometer. Functional capacity was measured with the 6 min walk test, the timed "up and go" test and a stair climbing test.
prevalence of neuropathy (40%) and obesity (53%) was high. Persons took a median of 6429 steps/day. In multivariate regression analysis, adjusted for age and sex, neuropathy was associated with a reduction of 1967 steps/day, decreased muscle strength with 1782 steps/day, and an increase in BMI of 1 kg/m(2) with a decrease of 210 steps/day (all p<0.05). Decreased muscle strength and BMI, but not neuropathy, were associated with outcome of functional capacity tests in multiple regression analysis.
peripheral neuropathy, decreased muscle strength and obesity are strongly associated with walking in persons with type 2 diabetes without manifest mobility limitations.
我们评估了糖尿病并发症和潜在病理与无明显活动受限的 2 型糖尿病患者日常步行活动的相关性。
研究了 100 名 2 型糖尿病患者（平均年龄 64.5 ± 9.4 岁）。排除有明显活动受限的患者。测量了可能的决定因素：周围神经病变、神经性疼痛、外周动脉疾病、心血管疾病、肌肉力量下降（手握力）、BMI、抑郁、跌倒和恐摔。使用计步器在一周内测量步行活动。使用 6 分钟步行测试、定时“起立行走”测试和爬楼梯测试测量功能能力。
周围神经病变（40%）和肥胖（53%）的患病率较高。患者平均每天行走 6429 步。在多变量回归分析中，校正年龄和性别后，周围神经病变与每天减少 1967 步相关，肌肉力量下降与每天减少 1782 步相关，BMI 增加 1 公斤/平方米与每天减少 210 步相关（均 p<0.05）。在多元回归分析中，只有肌肉力量下降和 BMI 与功能能力测试结果相关，而周围神经病变则无相关性。
周围神经病变、肌肉力量下降和肥胖与无明显活动受限的 2 型糖尿病患者的步行活动密切相关。
