Li Yan Qiu, Shan Zeng Chun
Stomological Hospital, Tianjin Medical University, Tianjin City, China.
J Oral Maxillofac Surg. 2011 Apr;69(4):994-1003. doi: 10.1016/j.joms.2010.05.008. Epub 2010 Oct 20.
The aim of the present study was to investigate the efficacy of microbial fiber membrane-Flagyl (MF-FLA) on facilitating hemostasis and wound healing and its anti-inflammatory ability after tooth extraction.
For the animal experiment, 60 healthy male rabbits were randomly divided into control and treatment groups. Each group included 5 subgroups corresponding to different experimental periods (1, 2, 4, 8, and 12 weeks) and each subgroup had 6 rabbits. After the different experimental periods, the rabbits were killed, and the mandible was removed for histologic examination and analysis. For the human trial, 80 patients (32 males and 48 females; age range, 13 to 32 years), who were undergoing orthodontic treatment and who had undergone bilateral extraction of teeth were included. For every patient, the left tooth socket was treated with biting gauze for 30 to 60 minutes as the control group. The right fossa was covered with MF-FLA as the treatment group. The wound was inspected visually, its depth was measured, and radiographs were taken at the different experimental periods (1, 2, 4, 8, and 12 weeks) to evaluate the wound healing effect.
In the animal experiment, the results of the histologic examination indicated MF-FLA could facilitate the growth of fibroblasts and osteoblasts and inhibit inflammatory cells. In the human trial, the clinical observation indicated that the MF-FLA treatment showed better hemostatic ability than the biting gauze. After 4 weeks, the wound depth of the control and treatment groups was 3.08 ± 0.05 mm and 1.26 ± 1.06 mm (P < .01), respectively. The radiographs showed that the treatment group was superior to control group in the degree and rate of wound healing.
The results of our study have shown that the MF-FLA can promote early wound healing and reduce the incidence of postextraction complications because of its biocompatibility, isolating and anti-inflammatory ability, and supporting the formation of blood clot in the tooth socket.
本研究旨在探讨微生物纤维膜-甲硝唑（MF-FLA）在拔牙后促进止血、伤口愈合的疗效及其抗炎能力。
动物实验中，60只健康雄性兔子随机分为对照组和治疗组。每组包括对应不同实验周期（1、2、4、8和12周）的5个亚组，每个亚组有6只兔子。在不同实验周期后，处死兔子，取下颌骨进行组织学检查和分析。人体试验中，纳入80例正在接受正畸治疗且已双侧拔牙的患者（32例男性和48例女性；年龄范围13至32岁）。对于每位患者，左侧牙槽窝用咬纱布处理30至60分钟作为对照组。右侧牙槽窝覆盖MF-FLA作为治疗组。在不同实验周期（1、2、4、8和12周）对伤口进行肉眼检查、测量深度并拍摄X光片，以评估伤口愈合效果。
动物实验中，组织学检查结果表明MF-FLA可促进成纤维细胞和成骨细胞生长并抑制炎性细胞。人体试验中，临床观察表明MF-FLA治疗的止血能力优于咬纱布。4周后，对照组和治疗组的伤口深度分别为3.08±0.05mm和1.26±1.06mm（P<.01）。X光片显示治疗组在伤口愈合程度和速度方面优于对照组。
我们的研究结果表明，MF-FLA因其生物相容性、隔离和抗炎能力以及支持牙槽窝内血凝块形成，可促进伤口早期愈合并降低拔牙后并发症的发生率。
