[中国汉族患者中PTPN22基因多态性与系统性红斑狼疮的相关性]
[Correlation between PTPN22 gene polymorphism and systemic lupus erythematosus in Chinese Han patients].
作者信息
Peng Xue-biao, Ou Li-na
机构信息
Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2010 Oct;30(10):2390-1.
OBJECTIVE
To investigate the association between 1858C/T single nucleotide polymorphism on exon 14 of the protein tyrosine phosphatase nonreceptor-22 (PTPN22) gene and systemic lupus erythematosus in Chinese Han patients.
METHODS
Forty Chinese Han patients with SLE and 20 normal control subjects were enrolled in the study, and PTPN22 gene 1858 C/T polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
RESULTS
No significant difference was found in the CC, CT, and TT genotype frequencies or in the C and T allele frequencies between the SLE patients and the normal controls.
CONCLUSION
1858C/T on PTPN22 gene might not be associated with the susceptibility of SLE in Chinese Han population.
目的
研究蛋白酪氨酸磷酸酶非受体22（PTPN22）基因第14外显子1858C/T单核苷酸多态性与中国汉族系统性红斑狼疮患者的相关性。
方法
本研究纳入40例中国汉族系统性红斑狼疮患者和20例正常对照者，采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析PTPN22基因1858 C/T多态性。
结果
系统性红斑狼疮患者与正常对照者在CC、CT和TT基因型频率以及C和T等位基因频率上均无显著差异。
结论
PTPN22基因1858C/T可能与中国汉族人群系统性红斑狼疮的易感性无关。
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