People's Hospital of Zhengzhou, Zhengzhou, China.
Asia Pac J Public Health. 2013 Jul;25(4 Suppl):22S-9S. doi: 10.1177/1010539513496268.
In this meta-analysis of the association between PTPN22 gene polymorphisms and susceptibility to systemic lupus erythematosus, 4 case-control studies, including one from China, were included. The studies included 1864 participants: 772 cases and 1092 controls. The meta-analysis showed that the 1858C/T polymorphism of the PTPN22 gene is correlated with systemic lupus erythematosus susceptibility, when assessed by distribution characteristics such as nationality, race, and region. A large sample size from the Chinese population is required for a further prospective study before causality can be established.
在这项 PTPN22 基因多态性与系统性红斑狼疮易感性关联的荟萃分析中，纳入了 4 项病例对照研究，其中包括一项来自中国的研究。这些研究共纳入了 1864 名参与者：772 例病例和 1092 例对照。荟萃分析显示，PTPN22 基因的 1858C/T 多态性与系统性红斑狼疮易感性相关，这种相关性可通过国籍、种族和地区等分布特征来评估。在确定因果关系之前，需要对中国人群进行更大样本量的前瞻性研究。
