Gobal Freij A, Mehta Jawahar L
Department of Internal Medicine and Physiology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR, USA.
Ther Adv Cardiovasc Dis. 2010 Dec;4(6):375-83. doi: 10.1177/1753944710385048. Epub 2010 Oct 21.
The elderly population is increasing worldwide. Despite a major decrease in deaths from coronary heart disease (CHD), this malady remains the major cause of death in elderly men and women. In this paper, we review the role of dyslipidemia as a major known risk factor in the pathogenesis of CHD, age-related changes in lipoprotein metabolism, and differences in changes in lipids that occur in men and women during aging. Next we provide an overview of the available studies and recommendations from ATP III. Finally, we comment on the screening and management, cost and side effects of therapy as it applies to an aging population.
全球老年人口正在增加。尽管冠心病(CHD)导致的死亡人数大幅下降,但这种疾病仍是老年男性和女性的主要死因。在本文中,我们综述了血脂异常作为冠心病发病机制中主要已知危险因素的作用、脂蛋白代谢的年龄相关变化以及衰老过程中男性和女性血脂变化的差异。接下来,我们概述了来自ATP III的现有研究和建议。最后,我们就适用于老年人群的筛查与管理、治疗成本和副作用发表评论。