Semel Institute Center for Community Health, University of California, Los Angeles, Los Angeles, CA 90024, USA.
Am J Public Health. 2010 Dec;100(12):2418-25. doi: 10.2105/AJPH.2009.185462. Epub 2010 Oct 21.
We examined findings from a randomized controlled intervention trial designed to improve the quality of life of people living with HIV in Thailand.
A total of 507 people living with HIV were recruited from 4 district hospitals in northern and northeastern Thailand and were randomized to an intervention group (n = 260) or a standard care group (n = 247). Computer-assisted personal interviews were administered at baseline and at 6 and 12 months.
At baseline, the characteristics of participants in the intervention and standard care conditions were comparable. The mixed-effects models used to assess the impact of the intervention revealed significant improvements in general health (B = 2.51; P = .001) and mental health (B = 1.57; P = .02) among participants in the intervention condition over 12 months and declines among those in the standard care condition.
Our results demonstrate that a behavioral intervention was successful in improving the quality of life of people living with HIV. Such interventions must be performed in a systematic, collaborative manner to ensure their cultural relevance, sustainability, and overall success.
我们考察了一项旨在提高泰国艾滋病毒感染者生活质量的随机对照干预试验的结果。
我们从泰国北部和东北部的 4 家地区医院招募了 507 名艾滋病毒感染者，并将他们随机分配到干预组（n=260）或标准护理组（n=247）。在基线和 6 个月及 12 个月时进行计算机辅助个人访谈。
在基线时，干预组和标准护理组参与者的特征具有可比性。用于评估干预影响的混合效应模型显示，在 12 个月内，干预组参与者的一般健康状况（B=2.51；P=.001）和心理健康状况（B=1.57；P=.02）显著改善，而标准护理组参与者的健康状况则下降。
我们的研究结果表明，行为干预成功地改善了艾滋病毒感染者的生活质量。这种干预措施必须以系统、协作的方式进行，以确保其文化相关性、可持续性和整体成功。
