Mishra P K, Bhargava A, Khan S, Pathak N, Punde R P, Varshney S
Bhopal Memorial Hospital and Research Centre, Bhopal, India.
Indian J Med Microbiol. 2010 Oct-Dec;28(4):358-62. doi: 10.4103/0255-0857.71813.
Characterisation of host immune response to hepatitis C virus (HCV) genotypes may have an important prognostic and therapeutic implication. Genotype-3 was more prevalent in the examined cohort and demonstrated a significantly higher response to combination therapy than genotype-1. Sustained virological response (SVR) was 94.74% in genotype-3 and 45.45% in genotype-1. The patients who achieved SVR reported higher levels of circulating T helper 1 cytokines in comparison to subjects with no SVR in both the studied groups. Besides providing local prevalence, our study might also assist in understanding the host immune mechanisms involved to achieve SVR during combination therapy in chronic HCV patients.
宿主对丙型肝炎病毒（HCV）基因型的免疫反应特征可能具有重要的预后和治疗意义。在研究队列中，3型基因型更为普遍，并且与1型基因型相比，对联合治疗的反应明显更高。3型基因型的持续病毒学应答（SVR）为94.74%，1型基因型为45.45%。在两个研究组中，实现SVR的患者与未实现SVR的受试者相比，循环辅助性T细胞1细胞因子水平更高。除了提供当地的流行情况外，我们的研究还可能有助于了解慢性HCV患者在联合治疗期间实现SVR所涉及的宿主免疫机制。
