Fukui H, Sato N, Kawano S, Yoshihara H, Hijioka T, Eguchi H, Goto M, Matsunaga T, Kubota-Kashio S, Kamada T
First Dept. of Medicine, Osaka University Medical School, Japan.
Adv Exp Med Biol. 1990;277:691-6. doi: 10.1007/978-1-4684-8181-5_78.
The effects of low (1 g/kg body wt) and high doses (4 g/kg body wt) of ethanol on hepatic oxygenation in rats was investigated employing an in vivo microscopic and spectrophotometric system and also a micro oxygen electrode. The low dose of ethanol increased sinusoidal blood hemoglobin oxygenation (ISO2) at periportal regions in the liver lobule. The high dose of ethanol increased ISO2 at periportal regions, but decreased ISO2 at pericentral regions. The low dose of ethanol increased hepatic surface tissue PO2, but the high dose decreased this PO2. From these data it is concluded that the increase of hepatic blood flow, after administration of a low dose of ethanol, compensated for the increase of oxygen demand in hepatocytes but that administration of a high dose of ethanol reduced hepatic tissue oxygenation via an imbalance between delivery and demand of oxygen in pericentral regions of the liver lobule, resulting in local hypoxia in surface hepatic tissue.
采用体内显微镜和分光光度系统以及微氧电极，研究了低剂量（1克/千克体重）和高剂量（4克/千克体重）乙醇对大鼠肝脏氧合的影响。低剂量乙醇增加了肝小叶门周区域的肝血窦血红蛋白氧合（ISO2）。高剂量乙醇增加了门周区域的ISO2，但降低了中央周区域的ISO2。低剂量乙醇增加了肝脏表面组织的PO2，而高剂量则降低了该PO2。从这些数据可以得出结论，低剂量乙醇给药后肝血流量的增加补偿了肝细胞中氧需求的增加，但高剂量乙醇给药通过肝小叶中央周区域氧输送与需求之间的不平衡降低了肝组织氧合，导致肝脏表面组织局部缺氧。
