大鼠肝小叶内血红蛋白氧饱和度的体内估计。

In vivo estimation of oxygen saturation of hemoglobin in hepatic lobules in rats.

作者信息

Eguchi H, Sato N, Matsumura T, Kawano S, Kamada T

机构信息

Department of Medicine, Osaka University Medical School, Fukushima-ku, Japan.

出版信息

Adv Exp Med Biol. 1988;222:591-6. doi: 10.1007/978-1-4615-9510-6_72.

DOI:10.1007/978-1-4615-9510-6_72

PMID:3364285

Abstract

We developed a system for the in vivo estimation of oxygen saturation of hemoglobin in the sinusoidal blood of periportal and pericentral regions of hepatic lobules in rats. There was a marked heterogeneity in blood oxygenation and oxygen gradients within hepatic lobules. The sinusoidal blood oxygenation was reduced in some pericentral regions within hepatic lobules following acute ethanol ingestion, suggesting an occurrence of perivenular hypoxia in the liver after acute ethanol consumption.

摘要

我们开发了一种用于体内估计大鼠肝小叶门静脉周围和中央周围区域窦性血液中血红蛋白氧饱和度的系统。肝小叶内血液氧合和氧梯度存在明显的异质性。急性摄入乙醇后，肝小叶内一些中央周围区域的窦性血液氧合降低，提示急性摄入乙醇后肝脏出现静脉周围缺氧。