Bessière Baptiste, Laboureyras Emilie, Laulin Jean-Paul, Simonnet Guy
Université Bordeaux 2, Université Bordeaux 1, CNRS, Bordeaux France.
Neuroreport. 2010 Dec 29;21(18):1167-71. doi: 10.1097/WNR.0b013e328340d7f6.
Rats received an intraplantar carrageenan injection for inducing hind paw inflammation. After 1 h 45 min, they were exposed to medical air (air group), xenon 25% (Xe-25 group) or 50% (Xe-50 group) for 1 h 45 min. Mechanical nociceptive threshold was evaluated on experimental day and once daily for 1 week. Beyond the well-known antinociceptive effect of xenon, the delayed hyperalgesia observed for 4 days after carrageenan injection was strongly reduced in Xe-25 group and totally suppressed in Xe-50 group on the inflamed hind paw. Moreover, delayed hyperalgesia on the noninflamed hind paw was totally suppressed for both the xenon concentrations. These results show that xenon, beyond its antinociceptive effects, may be a fruitful therapeutic strategy to limit the development of pain sensitization after tissue injury.
大鼠接受足底注射角叉菜胶以诱导后爪炎症。1小时45分钟后，它们暴露于医用空气（空气组）、25%氙气（Xe-25组）或50%氙气（Xe-50组）中1小时45分钟。在实验当天及之后的一周内每天评估一次机械性伤害感受阈值。除了氙气众所周知的抗伤害感受作用外，角叉菜胶注射后观察到的延迟性痛觉过敏在Xe-25组中显著减轻，在Xe-50组中，炎症后爪的延迟性痛觉过敏完全被抑制。此外，两种氙气浓度均完全抑制了未发炎后爪的延迟性痛觉过敏。这些结果表明，氙气除了具有抗伤害感受作用外，可能是一种有效的治疗策略，可限制组织损伤后疼痛敏化的发展。
