原发性皮肤淋巴瘤的免疫表型诊断：给皮肤科执业医师的综述
Immunophenotypic diagnosis of primary cutaneous lymphomas: a review for the practicing dermatologist.
作者信息
Campbell Shannon M, Peters Sara B, Zirwas Matthew J, Wong Henry K
出版信息
J Clin Aesthet Dermatol. 2010 Oct;3(10):21-5.
Abstract
The application of CD markers to medicine has advanced our understanding of several dermatological diseases, most notably primary cutaneous lymphomas. CD markers are monoclonal antibodies that target cell surface molecules on leukocytes and antigens from other cells. T-cell processes are typically CD3+, CD20-, CD45+ while B-cell processes are typically CD3-, CD20+, and CD45+. Other CD markers are used to further delineate cutaneous lymphomas. Although an imperfect system, CD markers empower dermatologists to synthesize immunophenotyping with clinical findings and formulate an appropriate diagnosis.
摘要
CD标志物在医学上的应用增进了我们对多种皮肤病，尤其是原发性皮肤淋巴瘤的了解。CD标志物是针对白细胞上的细胞表面分子以及其他细胞抗原的单克隆抗体。T细胞过程通常为CD3阳性、CD20阴性、CD45阳性，而B细胞过程通常为CD3阴性、CD20阳性、CD45阳性。其他CD标志物用于进一步区分皮肤淋巴瘤。尽管这是一个并不完美的系统，但CD标志物使皮肤科医生能够将免疫表型分析与临床发现相结合，并做出恰当的诊断。
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