硅二烯酸酯与原位生成的硅路易斯酸催化的α,β-不饱和醛的 1,4-加成反应。
1,4-Addition of silicon dienoates to α,β-unsaturated aldehydes catalyzed by in situ-generated silicon Lewis acid.
机构信息
School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
出版信息
Chem Commun (Camb). 2010 Dec 14;46(46):8728-30. doi: 10.1039/c0cc02438d. Epub 2010 Oct 22.
PMID:20967390
Abstract
In situ-generated silyl methide species (R(3)Si-CTf(2)R') effectively catalyzed the reaction of β-substituted α,β-unsaturated aldehydes with silicon dienoates such as 3-bromo-2-TESO-furan to give the corresponding γ-adducts with excellent 1,4-selectivity and good anti selectivity.
摘要
原位生成的硅甲基（R(3)Si-CTf(2)R'）物种有效地催化了β-取代的α,β-不饱和醛与硅二烯酯（如 3-溴-2-TESO-呋喃）的反应，以优异的 1,4-选择性和良好的反选择性得到相应的γ-加合物。
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