Suzuki N, Hirose Y
Tokyo Medical and Dental University, Japan.
Anesth Prog. 1990 Jul;37(4):190-3.
The effect of midazolam on the rat thalamic-evoked responses in ventrobasal complex following strong electrical stimulation of the upper lip was investigated. The animals received i.p. doses of 5, 10, 20 mg/kg midazolam, or physiological saline. Relative amplitudes of the large negative potentials, which were considered to be an excitation of ventrobasal cells, were not suppressed after midazolam injection. No significant differences were found in latencies of the potentials before and after administration of the drug. It is suggested that the effective sites of midazolam may not be located at a diencephalon level.
研究了咪达唑仑对大鼠上唇强电刺激后腹侧基底复合体丘脑诱发反应的影响。动物腹腔注射5、10、20mg/kg剂量的咪达唑仑或生理盐水。被认为是腹侧基底细胞兴奋的大负电位的相对幅度在注射咪达唑仑后未被抑制。给药前后电位潜伏期未发现显著差异。提示咪达唑仑的有效作用部位可能不在间脑水平。
