Luyk N H, Weaver J M, Quinn C, Wilson S, Beck F M
College of Dentistry, Ohio State University, Columbus.
Anesth Prog. 1990 Sep-Oct;37(5):238-43.
Despite its many disadvantages, succinylcholine is the most commonly used drug for intubation of patients for short out-patient procedure. This double blind trial compared a low dose atracurium/lidocaine combination to succinylcholine for intubation in 40 ASA1 adult patients. Low dose atracurium/lidocaine provided clinical intubating conditions at two minutes and cardiovascular stability equivalent to succinylcholine with significantly less myalgia. Spontaneous respiration was slower after low dose atracurium/lidocaine relative to succinylcholine. Low dose atracurium/lidocaine may provide an acceptable alternative to succinylcholine for intubation in short outpatient procedures.
尽管琥珀酰胆碱有诸多缺点，但它仍是门诊短期手术患者插管时最常用的药物。这项双盲试验比较了低剂量阿曲库铵/利多卡因组合与琥珀酰胆碱用于40例ASA1级成年患者插管的效果。低剂量阿曲库铵/利多卡因在两分钟时提供了与琥珀酰胆碱相当的临床插管条件和心血管稳定性，且肌痛明显减轻。与琥珀酰胆碱相比，低剂量阿曲库铵/利多卡因后自主呼吸较慢。低剂量阿曲库铵/利多卡因可能为门诊短期手术插管提供一种可接受的替代琥珀酰胆碱的方法。
