德尔福黄花中的三萜类化合物。

Terpenoids from the aerial parts of Parasenecio deltophylla.

机构信息

State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.

出版信息

J Nat Prod. 2010 Nov 29;73(11):1954-7. doi: 10.1021/np1004505. Epub 2010 Oct 22.

DOI:10.1021/np1004505

PMID:20968296

Abstract

Five new modified eremophilane-type sesquiterpenes (1-5), including three norsesquiterpenes (1-3), and one new monoterpene (6) were isolated from the aerial parts of Parasenecio deltophylla. Their structures were established on the basis of HRMS and NMR methods. The cytotoxicity of compounds 1-4 and 6 against selected cancer cell lines, including human promyelocytic leukemia (HL-60) and human hepatoma (Hep-G2), was evaluated. Antioxidant activities of these compounds were assessed by ABTS and DPPH methods.

摘要

从獐牙菜属植物的地上部分分离得到了五个新的修饰的半日花烷型倍半萜（1-5），包括三个去甲倍半萜（1-3）和一个新的单萜（6）。基于高分辨质谱和核磁共振方法确定了它们的结构。对化合物 1-4 和 6 对选定的癌细胞系（包括人早幼粒细胞白血病（HL-60）和人肝癌（Hep-G2））的细胞毒性进行了评估。通过 ABTS 和 DPPH 方法评估了这些化合物的抗氧化活性。